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Progesterone doesn't work in me!

I'm a 29 year old lady, and work for a family doctor. I'm married and have been trying to concieve for four years. I underwent many IVF (In Vitro Fertilization) cycles (three times), yet none worked.

What is hapenning with me is that I take progesterone tablets or vaginal ovules in the two-week period after the embryo transfer (as a luteal support) but I develop a severe abdominal pain (period pain) and bleeding just one week after the transfer, and I lose the pregnancy... I feel that progesterone is ineffeceive in stabilizing my endometrium (uterus) to achieve a pregnancy. Its receptors might not work well or are absent or insensitive... I'm dying to have a baby... can anyone tell me if he/she has any idea about what I'm talking about? What to do? please help me and take my story and suffering seriously....

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Sep 27, 2007
 Progesterone doesn't work in me!
by: Wray

Hi there, I would say your oestrogen level is too high. Progesterone activates the oestrogen receptors, so when first using it, any oestrogen you have will be activated. This will cause a number of 'adverse' symtoms, some of which you describe. Not due to the progesterone itself, but to the oestrogen.

I would suggest you start using progesterone now, go through the symptoms you describe whilst not pregnant. That should balance the oestrogen, and then try to conceive. Avoid using the oral route, as 90% is destroyed by the gut and the liver as it passes through. Suppositories/pessaries, the cream, injections are all far more affective.

All the successful studies done on progesterone have used between 100-200mg/day, which equates to 3-6ml of our cream. I feel this is the dose you need, it's similar to that produced in the body during the luteal phase. Take care Wray
Feb 18, 2008
 lupus anti coagulant?
by: Anonymous

Have you been checked for the lupus anti coagulant disorder? It's a blood disorder that causes the body to clot off against the developing baby, resulting in miscarriage.

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