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Progesterone and TRT for men

by Greg
(Big Pine, CA)

DHT levels in men can cause lots of problems. if you are a man taking transdermal testosterone, your DHT levels can go right through the roof! If your DHT levels are low to begin with, this might be of benefit, but I'll bet there are more men out there with high DHT than low. In my case, just 4 pumps a day of Androgel is causing my DHT levels to go out of range on the high side. My hair is coming out, and I'll bet DHT plays some kind of role in BPH. I am trying Natpro in hopes of bringing the DHT down without having to resort to finasteride. If you were to sell your progesterone with a pre metered pump top, this would help us guys know exactly how much we are actually getting. If you are a guy, just a word of caution: Do not apply transdermal testosterone to the scrotum! this area is especially sensitive to DHT conversion and i guarantee you your DHT levels will skyrocket. I am currently also taking 1/4 arimidex EOD to bring estradiol down into an acceptable range. your thoughts on how all this works is appreciated.

Comments for Progesterone and TRT for men

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Dec 16, 2011
 calcium d-glucarate
by: Anonymous

You might want to consider going on calcium d-glucarate. It helps remove used hormones and toxins. If you do go on it you should also go on probiotics.
Dec 17, 2011
 Progesterone and TRT for men
by: Wray

Hi Greg You don't say why you need the testosterone, so I'm taking a guess in my reply. If it's for a reduced libido, you might consider using just the progesterone. There's reason to believe that it's progesterone that increases it, and not testosterone, see here. These are a few more papers on progesterone, see here, here, here and here. You'll find your hair won't fall out either. Progesterone is a natural 5-alpha reductase inhibitor, but with none of the side effects of finasteride, see here. It will also suppress any excess oestrogen you have, far safer than arimidex. I assume you are taking this to prevent gynecomastia forming from using the testosterone? You might like to see our page on Man Boobs. It alarms me all the drugs needed to combat the effects of using testosterone. FSH stimulates the enzyme aromatase in both men and women. Progesterone inhibits FHS. Giving an aromatase inhibitor to prevent oestrogen production, is rather like mopping up water while leaving the tap running. Why not turn off the tap? These are a few papers on progesterone, aromatase and oestrogen, see here, here, here, here, here, and here Continued below.
Dec 17, 2011
 Progesterone and TRT for men Part 2
by: Wray

Hi Greg On the libido side, if I'm on the right track, has anyone checked your prolactin levels? Or dopamine? Prolactin suppresses dopamine which is needed for a normal sexual response, see here, here,here, here and here. Progesterone suppresses excess prolactin, see here, here, here, here, here, here, here here and here. The amino acid tyrosine is the precursor to dopamine, if stressed levels of tyrosine drop, hence the drop in dopamine. Supplementing with tyrosine suppresses prolactin if high and increases dopamine. The rate limiting step in dopamine synthesis is the enzyme tyrosine hydroxylase. Insufficient levels of vitamin D inhibit tyrosine hydroxylase, resulting in a disturbance in the dopamine pathway. Please have a vitamin D test done, levels are low in most of us. It's needed by every cell to function normally, it's also a potent antioxidant. It's low in all cancers, including prostate cancer. Levels fall during winter, but so do testosterone levels, when were yours checked? Vitamin D deficient men have low testosterone, supplementing increases their level of testosterone, see here and here. It seems a far safer course to take vitamin D, it's also needed for the anagen phase of hair growth. Continued below.
Dec 17, 2011
 Progesterone and TRT for men
by: Wray

Hi Greg For more info on levels, testing etc see GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. And the minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. I've also seen a query from you via our admin contact form. I hear your point, more info is needed for men. Unfortunately there is only me, as it is I battle to keep up with all that's needed to be done. I've given you one page on men, there is another, although far more work is needed on it, but there are comments from other men you might like to look through, see here. I also understand your request for a pump action with a measured amount. I've thought about this, as it does make things easier, but for one fact. How much should it dispense. Some men need only 10mg/day, this would be 1/3ml of cream, some need 100mg/day which requires 3ml of cream. But at the other extreme we have women using 1000mg/day, which uses 1/2 of the entire tube in one day. Talking of ultra high amounts, there's no harm if men use these too. TBI victims are given over 1200mg/day via IV transfusion to prevent oedema and inflammation occurring, see here,and here. Over 70% of victims are men. I hope I've given you the correct papers, it appears you don't have BPH or cancer, I'm sure you would have mentioned it. Take care Wray
Feb 18, 2012
 Progesterone seems to help me
by: David G. Mills

I am 61 and on androgel (topical testosterone) because I have very low luteinizing hormone. Before androgel I was taking testosterone shots. I quikly developed both gynocomastia (very sore tits) and my scrotal sack shrank and my testicles were often ice cold on the shots and I still had the same problems to a lesser extent on the androgel.

Taking progesterone cream stopped those two adverse side effects almost instantly. Literally overnight. So since I will be taking testosterone for the rest of my life, I will be taking progesterone with it.

Initially I did have severe itching from taking progesterone cream and so I had to decrease the amount I was taking initially and gradually build up the dosage over a month. After a couple of months I still itch some but it is mild and gradually reducing.

I also have a slightly enlarged prostate which has caused me difficulty in urinating for many years. That condition seems to be gradually improving with progesterone as well, so we shall see what happens long term.

I am also curious to see if progesterone helps with hair loss. I have a pretty good head of hair for my age but nothing like it once was. I have read on a blog somewhere where a guy reported that after eight months a significant amount of his hair returned after being lost. So far I can't tell much improvement in the hair loss area but if it takes 8 months to get noticeable results I would still have about 5 months to go.
Feb 19, 2012
 Progesterone seems to help me
by: Wray

Hi David There still seems some controversy about giving men testosterone. There are many papers about this on our page Man Boobs. It doesn't appear dangerous in terms of prostate health, but does cause other adverse side effects, as you've noticed. Why not try just using the progesterone for a while, and no testosterone. Many men have benefitted with this only, see here, here here, here, here, here and here. The itch could be due to the other ingredients in the cream, have you checked them? Progesterone is excellent for BPH, as you'll see from one of the comments made. Progesterone has had some success with hair loss, but not in all men. I would suggest you have a vitamin D test done. Not only is this vital for the anagen phase of hair growth, but it does raise testosterone levels, see here and here. For more info on vitamin D levels, testing etc see GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray
Feb 19, 2012
 Progesterone and Testosterone supplementation
by: David G. Mills

In my case, which I know is not usually the case with low testosterone, I produce no luteinizing hormone. Without the luteinizing hormone I don't see how I could produce any testosterone with progesterone supplementation alone and the testosterone therapy has done many favorable things.

Testosterone has greatly increased my strength, my libido, my stamina, muscle weakness and pain, and has helped with pain from old sports injuries and surgeries. It has been particularly helpful with my back which has really bothered me since low back surgery (disc removal) 12 years ago. The higher the dosage of testosterone, the better my back feels, but I have to balance that with the side effects, which progesterone seems to greatly reduce.

I think I need them both unless there are some studies which indicate that low progesterone is the reason for low lutenizing hormone. And my low lutenizing hormoney could be due to low stimulating hormones from the hypothalmus causing the pituitary to produce low amounts of lutenizing hormone. I was tested for a pituitary tumor and an MRI showed none. So testosterone therapy was the easy answer.

I have also been an Atkins dieter for 15 years so I think my estrogen levels are not as bad as they could be, but they were still pretty bad. I was put on testosterone shots (200mg per week -- twice the usual dose) and I quickly got better. But at those levels I got acne and the other side effects of shrunhen scrotal sac and gynocomastia.

I also had low vitamin D and have been replacing it at 5000 units per day, but I am not consistent with this so I will try to do better.

Initially I used progesterone cream but have switched to a 100% water based gel which seems to cause me less itching. But maybe I could just be getting used to progesterone. I haven't gone back to creams to see if they make me itch more.
Feb 20, 2012
 Progesterone and Testosterone supplementation
by: Wray

Hi David I'm delighted the testosterone has helped, and that progesterone has negated the adverse side effects. It's interesting you ask about progesterone stimulating LH, it certainly does in females, "The newly synthesized neuroprogesterone acts on estradiol- induced progesterone receptors in nearby neurons to initiate the LH surge", see here and here. Another study says "One of the most dramatic differences involves estrogen positive feedback, which leads to ovulation. A crucial feature of this positive feedback is the ability of estradiol to facilitate progesterone synthesis in female hypothalamic astrocytes. Conversely, estradiol fails to elevate hypothalamic progesterone levels in male rodents, which lack the estrogen positive feedback-induced luteinizing hormone (LH) surge." A later study found it wasn't the oestrogen feedback that induced the LH surge, but progesterone, see here. It seems progesterone might do the same for men see (link to research article no longer active). Unfortunately a search has revealed nothing more. Probably because progesterone is firmly fixed in most minds as a female sex hormone, when it's neither. Hence the dearth of studies in men, apart from the ongoing TBI studies. As a follower of the Atkins diet, you might also be interested in the Paleo diet. There's a link to Dr Cordain's site on our Nutrition page. Incidentally oestradiol can detach dihydrotestosterone (DHT) from its binding sites on SHBG, thus making it more bioavailable. Dropping testosterone, and rising oestrogen are often checked in men, but progesterone…never! It would be interesting to find if in fact progesterone levels were dropping too, as it effectively suppresses oestrogen. Plus it does stimulate testosterone synthesis according to that study. And hCG was that checked, as this stimulates aromatase activity? Impaired glucose tolerance also reduces testosterone levels. I take it they did check your prolactin levels, as excess prolactin suppresses the pituitary secretion of dopamine. Continued below.
Feb 20, 2012
 Progesterone and Testosterone supplementation Part 2
by: Wray

Hi David Dopamine is essential for a normal sexual response, see here, here, here, here and here. But the rate limiting step in dopamine synthesis is the enzyme tyrosine hydroxylase. Insufficient levels of vitamin D inhibit tyrosine hydroxylase, resulting in a disturbance in the dopamine pathway. Re the gel you're now using, one study found the emulsion type base had a higher peak plasma concentration than the gels, see here. So if the gel doesn't work, you can always switch back again. Take care Wray
Feb 20, 2012
 Saw the doctor today
by: David G. Mills

Very typical MD and told him what I was doing. Of course, since he only practices main stream medicine (his term) and could find no hint that main stream medicine suggests usage of progesterone in men, he would not approve of my usage of it but would not insist I stop either since I told him it had helped with testosterone side effects.

It was time to do my normal bloodwork so he went ahead and added a testosterone level check as well as a luteinizing hormone check. Prior to taking testosterone my luteinizing hormone level was 2 and after taking testosterone, it had decreased tenfold to .2. So I will be curious to see what happens to the level after having had progesterone for a couple of months.
Feb 22, 2012
 Saw the doctor today
by: Wray

Hi David There are so few studies done solely on men or male animals, but as for men using it… the sky will fall down when main stream medicine suggests it to a man! As it is women have an uphill struggle, even though it's regarded as a female hormone. I'm a trifle puzzled by something, as earlier you said you didn't make LH, but now you say your level was 2. This falls into the normal range of 1.24-7.8 IU/L, see WebMD. It's now dropped due to the TRT, which it should do. I will be interested to hear if it's risen, although it might remain suppressed by the TRT. Take care Wray
Feb 22, 2012
 My LH
by: Anonymous

On the scale on my lab studies I was at the very bottom of normal, which I think on that scale was 2.0. But I am curious to see if LH changes while on progesterone even if on testosterone therapy.
Feb 23, 2012
 My LH
by: Wray

Hi David Ah I see now, the reference I used was from WebMD. For some reason Medline don't give reference ranges for men, only women. Do let me know the results, I'm intrigued. Take care Wray
Mar 03, 2012
 LH and Progesterone update
by: Anonymous

My LH was 1.8. When I was first tested before testosterone therapy it was 2.1. Then with a huge amount of testosterone (200mg per week by shot) it went to less than .1 and my testosterone level shot to over 1000. So after being on Androgel for six plus months and Progesterone for two plus months, my LH has come back to where it was when I started, but that was too low to produce enough testosterone.

I am also on statins (Crestor) for cholesterol and unfortunately (???) my cholesterol went up after being on progesterone -- from 165 to 216. But the good news is that my ratio got even better and went from 3.8 to 3.3. HDL went from 43 to 65. On the downside VLDL went from 17 to 22 and LDL from 105 to 129. Still happy though because my HDL has never been this high and the last time I had a ratio this good was in 8/2008.

Prostate seems to be improving and I swear I am regrowing hair.

Been taking two pumps of gel per day, which may be higher than Dr. Lee recommended, but since I am taking it for symptoms, I thought I needed to up the dose. But truth be known, I really don't know what two pumps per day of water based gel equates to. 4.4oz bottle and 500 mg per oz. But what each pump equates to the bottle does not say.
Mar 03, 2012
 My dosage
by: Anonymous

Went to the website of the gel I am using and according to it a pump is 17mg so I have been taking 34 mg per day.
Mar 04, 2012
 LH and Progesterone update
by: Wray

Hi David Thanks so much for coming back to me. I'm delighted your LH has risen, which it should have done, given the info in those papers I gave you. Here's hoping it rises high enough to increase testosterone levels. We have many men using amounts of progesterone far higher that that recommend by Dr Lee, up to 400mg/day in one case. I'm also delighted your HDL:LDL ratio has improved. Have you had a vitamin D test done yet? I gave you those papers on how it increases testosterone, but at the time I gave them to you, you didn't mention being on statins. It appears cholesterol levels are directly related to vitamin D levels. The lower the vitamin D the higher the cholesterol, please have a test. Ironically it appears the statins raise vitamin D slightly, which is one reason given for why they work, see here and here. You might like to read these papers too, see here, here and here. Plus these here and here. Take care Wray
Mar 04, 2012
 Vitamin D
by: David G. Mills

My Vitamin D was 23.7. A little low so I have been taking more of it. In the summer I get plenty of sunshine (I live in Memphis, TN) so my vitamin D levels are not as bad then. The days are getting longer now and the weather is getting better so hopefully soon my vitamin D will get back to better levels. I have been taking 5000 units daily so hopefully that will help as well.
Mar 05, 2012
 Vitamin D
by: Wray

Hi David 23.7ng/ml is very low! Blood levels should be 70-100ng/ml and not the 30ng/ml or most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day. Please read through those sites I gave you, and try to get your vitamin D level up to the 100ng/ml level. I'm sure that will make a world of difference to you. Memphis lies 35 degrees north, just within the 37 degree parallel of getting enough sun in summer. Although some say 33 degrees north is the line we should take. It's not so much the sun and feeling it on our skin, but the angle in arrives on earth, if too far north it's too oblique to make any. The best indication of making vitamin D, is if your shadow is shorter than you are when in the sun. But I'm pleased you're taking 5000iu's, although it will take some time to rise on that level. Take care Wray
Jul 09, 2012
 Update
by: David G. Mills

I notice my comments above were listed as anonymous so I will try to pay more attention when I post.

Just an update. I know I have grown hair on my wrists which now appear to have the hair I always had on my arms when younger but which I had lost. It seems like I am also growing hair on my ankles where I have lost hair as well and it seems like I have more on my head.

Go to get new labs next month.

I see two doctors -- one for testosterone and the other is an internist. I had reported on the internist before who said he only practices main stream medicine.

Just saw my testosterone doctor. My testosterone doctor was even worse than my internist. My testosterone doctor says he was a biochemist before he became an MD. His comment about bio identical progesterone was that bio identical hormones were a bunch of nonsense (funny since he is prescribing bio identical testosterone). His comment about using progesterone topically is that progesterone does not get absorbed through the skin very well. I told him that after using it many of my symptoms from taking testosterone had subsided. He attributed that to a placebo effect. I thought that was odd since I had no idea what taking progesterone would even do for me. I simply told him that I wasn't going to argue with him.

The group think in medicine is just ridiculous.
Jul 11, 2012
 Update
by: Wray

Hi David I did realise all the anon comments were you, as the context made sense. I'm delighted you have noticed more hair growing where you want it. It's so strange how dismissive doctors are about bio hormones. Yours seems particularly daft by disparaging them when he's prescribing them! Evidently he hasn't read any of the progesterone papers, probably because it's fixed in his mind that it's a female hormone. There's ample evidence that progesterone is absorbed well through the skin, see here and here. We run Saliva Tests too, and judging by the huge increase in levels, it's well absorbed. There is also a wonderful story on our Traumatic Brain Injury page, where a mother used the cream on her step son whilst in a coma. Normally it's given via IV transfusion to the men, but it seems it works as well in cream form. As you've found. To say that it's a placebo effect is also daft, one could easily turn to him and say therefore the TRT cream is also having a placebo effect! I can only agree with your last sentence, and thank you for coming back with this good news. Take care Wray
Jul 12, 2012
 One other thing -- Pemphigus
by: David G. Mills

Last year my doctor diagnosed me with pemphigus which is an autoimmune disease that affects the skin. There are three different kinds of pemphigus and the worst kind has a high mortality rate. Fortunately I have the mildest type. Pemphigus is a delamination of the layers of the skin and where the skin delaminates, the space fills up with fluid.

My symptoms began eleven years ago. The lesions I get look very similar to pimples except instead of pus they have clear fluid. And they don't heal. I have had lesions last months before they went away.

The standard treatment is cortisone but which can not be given for any length of time (usually about 30 days and then they want you off of it).

So when I started my progesterone regimen for the HRT side effects, I also had in mind whether progesterone would help this. After seven or so months on progesterone, my skin is better than it has been in the last ten years. I put an erythromycin-benzoyl peroxide topical gel on my lesions to help heal them quicker.

The combination of progesterone and the erythromycin-benzoil gel has produced a slow but steady improvement of a condition that has been a real painful nuisance as well as somewhat disfiguring from the scars the lesions leave.

So I think this is proof that progesterone will work as a substitute for cortisone with the added benefit that you can continuously take it without the concern for the side effects of cortisone.
Jul 13, 2012
 One other thing -- Pemphigus
by: Wray

Hi David I couldn't be more delighted with this news! As you say, pemphigus is an 'autoimmune' disease, I do confess I doubt such a thing exists. I believe they could all well be caused by a lack of vitamin D, and possibly progesterone too. Both these activate transcription factors, which work to regulate gene expression. If a lack presents itself the cell will malfunction. So it's no wonder antibodies are produced. Low vitamin D is found in all autoimmune diseases, progesterone is low too in those where it's been checked. We do have more about this on our Progesterone and Vitamin D page. You said your vitamin D was low, please have another test done. I feel you should get it up to 100ng/ml and keep it there for a few months. Then always keep it somewhere between 70-100ng/ml. I don't believe the 5000iu's you are taking will raise it quickly enough. Pemphigus affects the kerotinocytes, these have ample progesterone and vitamin D receptor sites. It appears the Th1 cytokine system is involved, this increases inflammatory substances like IL2. Both progesterone and vitamin D suppress the Th1 system and stimulate the Th2 system which produces anti-inflammatory cytokines like IL10. I did mention the gel based progesterone is not absorbed as well as the emulsion type. Please would you consider trying our cream. We do have a questionnaire you can fill in, it's found at the top of this page in the left margin. In doing this you are given a coupon code which gives you about 30% off the cost of the tube. I would be most interested if it helps you better than the gel. I have applied the cream directly to burns myself, and to a friend with a motor bike burn on his leg, it's the best substance there is for healing and pain reduction. Others have applied it to wounds to great effect. And one woman to an ulcer left after a squamous cell carcinoma had been removed, and wasn't healing with the topical drugs she'd been given. The inflammation reduced within a day, and there was barely a sign of the wound three weeks after using the progesterone. I would hope you won't need the antibiotic gel. Take care Wray
Jul 13, 2012
 Your cream
by: David G. Mills

Why is it not in coconut oil? Why is it not in a glass as some are?
Jul 15, 2012
 Your cream
by: Wray

Hi David It is in coconut oil. The caprylic/capric triglycerides (often called MCT oil) is a fractionated oil taken from coconut oil. Wiki explain fractionation here. It's an amazingly versatile oil, as it's used in ketogenic diets, for cancer patients, for weight loss, body builders use it for energy as it's not converted to or stored as fat, plus it's use in medical applications and cosmetics is vast. See here and here. 15 years ago we tried packing in glass, but the breakages were too great. Glass is fine if only selling to shops and it's transported directly to the outlet. But the bulk of our sales is via the post. The LDPE plastic we use is one of the safe plastics, see here, here, here here, here, and here. Take care Wray
Jul 16, 2012
 Coconut Oil
by: David G. Mills

If you wanted the properties of coconut oil's best preservative and antibiotic you needed to retain the lauric acid part of coconut oil.

http://www.lauric.org/

Best solution is coconut oil itself not capric and caprylic acid.

Talk to Mary Enig, best researcher on coconut oil.
Jul 17, 2012
 Coconut Oil
by: Wray

Hi David I'm delighted you're so interested in coconut oil. I do know Mary Enig's sites, in fact I often give her excellent info on soy to people wanting to know more. Lauric acid is a powerful antimicrobial, but so too is caprylic acid, see here, here, here, here, here and here. Unfortunately many people don't like the smell of coconut oil, and we wouldn't consider using a refined deodorised product. Due to the high content of lauric acid, coconut oil is also too thick to use in a cream, unless we wanted a very thick one. Because caprylic acid has only 8 carbon chains, and capric 10, it's absorbed through the skin better than any other oil due to the small molecular size. This means the progesterone is absorbed far better too. Lauric acid has a 12 carbon chain molecule making it slightly less absorbable. Hope this explains why we use it. Take care Wray
Jul 17, 2012
 True, but
by: David G. Mills

Lauric acid is the compound in human milk responsible for helping babies fight infections. It is a much better antimicrobial than either capric or caprilic acid. I don't know that means much in this context, except that it would help with preservation and you would not need the preservatives. Coconut oil can sit on the counter for a year at room temperature without showing any signs of going rancid.

I like the highly refined coconut oil and dislike the coconut oil that is not highly refined. I don't like the taste or smell of coconut and the highly refined oil has no taste or smell yet has the same benefits of lauric acid.

It would be harder to pour since it is solid below 76 degrees.

I just know that Dr. Peat recommended using progesterone in coconut oil.
Jul 18, 2012
 True, but
by: Wray

Hi David Caprylic acid is also found in human milk! And how does one test 'better'? It's evident from those papers I gave you that caprylic acid is effective against many pathogens, if not they would have used the lauric acid. In fact it's more abundant than caprylic too, coconut oil containing ±50% and therefore cheaper than the caprylic. All but the small percentage of unsaturated fats found in coconut oil can sit for a year or more without going rancid, because of their short carbon chain length, i.e. because they are all saturated fats. I do understand Ray Peats argument about using whole coconut oil, but it would make too thick a cream. I can't find on his site where he says progesterone is best in coconut oil, but he does say it's best for health……."Various fractions of coconut oil are coming into use as "drugs," meaning that they are advertised as treatments for diseases. Butyric acid is used to treat cancer, lauric and myristic acids to treat virus infections, and mixtures of medium-chain fats are sold for weight loss. Purification undoubtedly increases certain effects, and results in profitable products, but in the absence of more precise knowledge, I think the whole natural product, used as a regular food, is the best way to protect health". So I use both caprylic and whole coconut oil in my cooking, on salads etc. As I'm still convinced caprylic acid has many benefits! Take care Wray
Feb 06, 2014
 androgel to scrotum
by: Anonymous

Applying androgel, testim etc. is actually one measure to take to reverse gyno. I forget the bodybuilder who had a protocol for reversing gyno ... this was one step along with cruciferous vegetables, reservatol & there were some other things too ....
Feb 26, 2014
 SHBG
by: emmett

I am a 80 year old man that felt older (if possible) than 80. I went to my long time dr. and blood was drawn. the results were as follows:

total testosterone 765.1 (348-1197ng/dl) my free 5.5% L (9-46), LH 9.7 H(1.7-8.6),FSH 3.5 N (1.5 12.4mIU/mL), SHBG 82.3 H (19.3-76.4. estradiol 31.4 N (7.6-42.6pg/mL

dr wrote script for compound cream 5% testosterone, 5% chrysin. after 3.5 months another blood sample drawn. results: it corrected my LD, total testerone 936, SHBG 116.4 kncrease of 34.1, estradiol40.6 increase of 2.4. these tests were done at LabCorp.

In conclusion: it did correct my LH. the rest was negative.I never did have progesterone checked, because dr. did not believe in it. I ask himfor a compound script but refused. I then ordered progesteron cr eam fron Cape Fear, but later learned about Natpro and ordered and was advised was shipped 2/24/14. I will see how that works for me. I have also been taking DIM for about 30 days.and I also take from LE a prostate product they sell. it has 320 mg of saw-palmetto with several ingredients. would like to here if anyone thinks this may be the missing factor in my battle to free my testosterone.

Thanks,
Emmett

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