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premature ovarian insufficiency (failure)

by robyn
(kihei)

hi there, i have p.o.i. premature ovarian insufficiency. i have been diagnosed and suggested to maintain a dose of 200mg progesterone and .5 of estradiol per day. i am wondering if anyone has found a healthy estradiol to use in conjunction with the natural progesterone. thank you

Comments for premature ovarian insufficiency (failure)

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Aug 11, 2013
 estradiol
by: Anonymous

Hi Robyn, I use the Vivelle dot, which is a patch. It is an bioidentical hormone that is fda approved.
Aug 11, 2013
 premature ovarian insufficiency (failure)
by: Wray

Hi Robyn As the anonymous suggests, Vivelle is natural oestrodiol. Elestrin and Estrogel are two in gel form, although the amount is 10 times lower than the amount you've been told to use. Vivelle has a variety of doses from 0.025, 0.0375, 0.05, 0.075, up to 0.1 mg. Even the highest amount will only give you 1/5th of your needs. MIMs has a number you could look at, see here. Scroll to 'Unopposed oestrogen (if uterus is intact an adjunctive progestogen must be used)' If you don't want to have children, or have had them, then there is no need to use the oestrogen. Progesterone is sufficient, it has no adverse side effects whereas oestrogen does. Please see our page on HRT. If the POI has sent you into Peri-menopause please take a look through this page. If you've been told you need the oestrogen to keep a cycle going including bleeding, you don't need that either. In fact here's evolutionary evidence we shouldn't be having the 400 plus periods in a lifetime, but nearer the 100 periods, see here. This is another worth reading, see here. Take care Wray
Aug 11, 2013
 P.O.I
by: robyn

thank you for your feedback...i appreciate it very much. to Wray, i was told i needed to take the estrogen to keep my bones protected from osteoporosis-is this not true? if i don't need it, i don't want to take it. thanks again, robyn
Aug 12, 2013
 P.O.I
by: Wray

Hi Robyn Ah I forgot about the 'oestrogen protecting the bones' view! I cannot believe they are still pushing that. We do have a page on Osteoporosis you could look through to make up your own mind. They always forget progesterone. As we age, actually from about 35 onwards, we begin getting anovulatory cycles where no progesterone is made. But testosterone and oestrogen are still secreted. This not only causes a possible worsening of PMS symptoms, see here, but means we are not building bone that month. Progesterone is involved in building bone, whereas oestrogen slows down the loss of bone. But we need this loss, bone building is a dynamic process. Old bone is removed to make place for new, so giving oestrogen means we are left with old bones. By the way the 200mg/day progesterone they suggested you use is an excellent amount, but not if it's oral. This is the least effective Delivery system, "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues", see here. So if you've been given capsules I suggest opening them and adding the contents to a small amount of skin cream and apply that to your skin, you'll get the full benefit of the progesterone, see here. Alternatively you could just get a progesterone cream. Take care Wray

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