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pmddloon

really very exstreamly serverly progesterone intollerant, please help how do i block progesterone natrually? thank you

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Apr 04, 2012
 pmddloon
by: Wray

Hi there I would have to know more about the symptoms you're experiencing to help. It seems unlikely you're intolerant to progesterone as we make over 400ng/ml per day during the third trimester of pregnancy. It could be you're experiencing Oestrogen Dominance symptoms. These occur in the few days prior to bleeding causing in some case severe PMS. It also occurs after giving birth, when progesterone also drops sharply. Sending many women into post natal depression. Oestrogen will suppress it, but I don't recommend this route, see our page on HRT as to why. Testosterone will suppress it too, but I certainly don't recommend this. Take care Wray
Apr 05, 2012
 pmdd with server progesterone intollerance
by: Anonymous

hi wray, no im defo intollerant to progesterone i only have 5 good days a month went loopy in pregnancy and any progesterone tab im given i tear the house to pieces and any1 who is around me. its proven i have pmdd with server progesterone intollerance and im breastfeeding which limits any meds at the mo. brain scans confirm progesterone changes the shape of gaba in the brain so pmdd's have so much activity in the brain that cant be dampened down and they go nuts. i need to block my natural progesterone?
Apr 06, 2012
 pmdd with server progesterone intollerance
by: Wray

Hi there Ah I didn't realise you were breast feeding, which means obviously you've just had a baby. In which case I'd say you don't have PMDD, but post natal depression (PND), possibly bordering on psychosis by the sounds of your symptoms. In which case you do need progesterone, a great deal too. It drops significantly after giving birth, sending 25% of women into some form of depression. From the baby blues, to post natal depression to post natal psychosis (PNP). So your level is currently rock bottom, nothing could make it go lower. You obviously had low levels in pregnancy too. High testosterone also causes depression, and low allopregnanolone, a potent metabolite of progesterone, also causes it. Allopregnanolone is a neuroactive steroid that enhances gamma aminobutyric acid (GABA) in the central nervous system, producing anxiolytic effects. The opposite of what you have been told. High copper can cause depression and psychosis, zinc is essential to lower the copper levels. High cortisol contributes to anxiety after birth too. The HPA axis also affects mood too. These are a few papers on PND, see here, here, here, here, here, here, here, here, here, here, here, here and here. Dr Dalton affectively treated PND with 800mg/day progesterone, and PNP with 2400mg/day progesterone, see here. She also wrote an excellent book about PND, see here. Continued below.
Apr 06, 2012
 pmdd with server progesterone intollerance
by: Wray

Hi there I think you'd need about 800mg/day, you might need more. The progesterone 'tab' would have made matters worse. If insufficient progesterone is used, it stimulates oestrogen, hence the worsening of symptoms. Please have your copper levels checked, as if high this has a significant bearing. Your testosterone too, if high progesterone effectively lowers it, by raising SHBG, see here. If you only have 5 good days a month, it appears you are severely oestrogen dominant. Progesterone can put this right too. Finally please have a vitamin D test done, a lack of this reduces the benefits of progesterone, and causes depression, see here, here, here, here and here. It's essential for the child too, see here and here. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray
Apr 07, 2012
 pmdd and server progesterone intollerance
by: Anonymous

hi wray, no i was diagnosed with pmdd before i was pregnant then in pregnacey i was diagnosedwith server progesterone intollerance on top. my oestrogen blood tests are good. my baby is now two and until recently ive felt brill with the breastfeeding and oestrogen. now my cycles are returning so to are pmdd progesterone symptoms. im going to start oxygen therapy but if you know of a progesterone blocker that would be brill. on being diagonsed with pmdd ive found that there is an oestrogen dominance pmdd, pmdd 'normal' and pmdd with server progesterone intollerance. also have you seen the bbc pmdd brain scan info with Dr Emily Stern of Cornell University. its very interesting also more info is found in more detail on the web about her experiment on this. x

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