Hi Margaret Oestriol is apparently a safe oestrogen, see here. It's also the one we produce during pregnancy, so one has to conclude from this that it must be. I've found Natpro to be excellent for myself, and use it nightly in my vagina. Progesterone is an anti-inflammatory, plus it inhibits the growth of candida in the vagina. If you have other menopausal symptoms, the oestriol won't help much, but the progesterone will. But if you have none, and only the vaginal problem, it's possible all you'll need is the oestriol. There's no harm in using both though. I suggest you use the one and see if you get any benefit, if not, then try the other. It will certainly be more cost effective if you only have to use one. You might like to see our page on Menopause for more info on how to use the progesterone. And please read our page on Oestrogen Dominance too, if you haven't been warned this can occur. Take care Wray
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