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Endless crying

by Anon
(Texas)

Hi wray love your info and website but I'm confused now I did everything possible to get rid of hot flashes ie vit d 10,000 ui 500mg prog magnesium and increasing organic meat protein. Well after 3 years of 200mg of natpro I increased to the 500mg and after 4 weeks the hot flashes stopped but now I feel severly depressed keep crying but no pain or anything else I thought I should feel better wby now I've got to admit when I had hot flashes I was motivated happy maybe a bit anxious but now I feel awful hope you can help thank you in advance

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Mar 05, 2013
 Endless crying
by: Wray

Hi there Thanks for the kind words. I'm delighted the Hot Flushes have stopped, but not that you seem to have gone backwards! I had endless crying too, but it was before I used progesterone. There's no knowing when progesterone will help, how it will or where it will. Increasing as you did stopped the flushes, but at the same time it has stimulated oestrogen. It's an excitatory hormone, it stimulates glutamate, our most excitatory neurotransmitter, see here. Excess glutamate causes havoc with emotions. Progesterone protects against glutamate toxicity, it also increases BDNF (brain-derived neuroptrophic factor) in itself protective, see here and here. If glutamate is too high, it allows calcium, an excitatory mineral, to enter the cells. Progesterone also protects against calcium induced excitotoxicity, see here. I can only ask you to continue as you are and hopefully the symptoms will pass quickly. I don't feel you need as much as 500mg/day, so when you do feel better, please try reducing by no more than 20mg per reduction. Please let me know if continuing with the high amount helps you. Take care Wray
Mar 07, 2013
 Endless crying
by: Anonymous

Thanks for replying wray, icant reduce the amount every time I try the hot flashes are back as a matter of fact some days they are still there even using 500mg. Also if I am still stimulating estrogen would I not have other symptoms. I have no bloating at all no breast pain or fluid retention as I used to a few years ago. I forgot to mention since the hot flashes are gone ( most of the time) I am constantly aware of my heart beating fast which was not there before and my libido is completely gone hope you can help already tried tyrosine with no help thank you
Mar 09, 2013
 Endless crying
by: Wray

Hi there Not necessarily, I've found stimulating oestrogen different symptoms can arise, but there's no telling which it will be. You do say you have no other symptoms, and yet say your heart is beating fast and your libido has gone since the hot flushes have gone. Both these are caused by excess oestrogen. Oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia, Torsades de Pointes and sudden death. Whereas progesterone shortens the QT interval, see here, here, here, here, here, here and here. We do have a page on Libido, maybe you've already seen it? If I'm correct and the increase in progesterone has triggered an oestrogen response, it would affect libido too. You are taking a good dose of vitamin D, but please have a test done, it could be it's still too low. A lack of this does impact on progesterone, plus it disturbs the dopamine pathway, dopamine is essential for libido. Although you have tried the tyrosine and it hasn't helped, it could be the vitamin D. The rate limiting step in dopamine synthesis is the enzyme tyrosine hydroxylase. Insufficient levels of vitamin D inhibit tyrosine hydroxylase, resulting in a disturbance in the dopamine pathway. I can only hope that your symptoms resolve soon, that it's too soon after the increase for it them settle down. We do have a page on Anxiety it does give a list of nutrients which help, please consider taking some. Taurine is a very calming amino acid, neurotransmitter too. It also calms the heart, please consider taking 1000-2000mg/day and see if that helps. Let me know how you get on. Take care Wray

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