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Disappointed and Confused

by Sherry
(Califiornia)

I started using natural progesterone cream about a year ago to control estrogen dominance and the onset of peri-menopause symptoms, as well as to keep a couple of small submucosal fibroids from growing. I'm now 43 years old.

I've been trying to get pregnant as well so I visited my gyn yesterday to discuss my chances, being that I'm now in peri-menopause. She did an ultra sound and to my utter horror and astonishment, she said one of the fibroids has grown so big that it's taking up the entire space of my uterine lining. This means that unless I have it removed, I won't be able to carry a baby because there literally isn't any place for the embryo to implant.

When I was finally able to digest all of this, I wondered if the progesterone cream could have caused the fibroid to grow so large so fast, so I did a little research. It seems that some doctors now believe that estrogen AND progesterone can cause fibroids to grow. There's even research being done now for a new fibroid treatment that will block progesterone, causing fibroids to shrink.

PLEASE use progesterone cream or any hormones for that matter with caution. I believe I caused that fibroid to grow out of control by using natural progesterone cream and now my chances of becoming a mother naturally are pretty much gone because I'm already in a race with time because of the peri-menopause. On top of that, I'll need surgery to remove that huge fibroid before I'll have any chance of carrying a baby to term. By the time I have the surgery and recover (all together this could take three months or more), I could in COMPLETE menopause or so far into peri-menopause, that it's too late to have children.

I'm devastated and extremely disappointed. I thought progesterone cream was the answer to hormonal problems, but it seems it just made things worse for me.

Comments for Disappointed and Confused

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Sep 17, 2013
 Disappointed and Confused
by: Wray

Hi Sherry It seems you were using the normal recommended amount of 20-40mg/day, is this the case? Even higher would have stimulated oestrogen, which would have caused the Fibroids to grow. Oestrogen and only oestrogen is a mitogen, causing cells to proliferate. Progesterone inhibits mitosis, but enough has to be used. If too low it will continue to stimulate oestrogen. This is something so few doctors understand, and so they blame progesterone. A study on tumour growth found exactly this, too little caused the tumour to grow, see here. Fibroids are caused by oxidative stress, removing the fibroid by surgery will still leave you with the oxidative stress, it's essential to take large amounts of antioxidants to reduce the Inflammation. One of the most powerful antioxidants is vitamin D. It appears a low level causes fibroids to grow, taking it certainly reduces them, see here, here, here, here, here and here. Please have a test done. Too little progesterone makes matters worse for so many people, this website is littered with complaints from women. Too little vitamin D will also make matters worse, as a low level reduces the benefits of progesterone. Take care Wray
Sep 30, 2013
 Confused
by: Debbie

Hi Wray,
I've been studying menopausal and bio identical hormones for 6 years now and I'M STILL CONFUSED. I HAVE BEEN MENOPAUSAL SINCE 47 IM 52 NOW. a YEAR AGO I STARTED TO USE A BIO IDENTCAL ORGANIC PROGESTORONE CREAM FROM A GREAT PLACE I SHOP FOR WITH MY VITAMINS AND HERBS TOO. I STARTED TO HAVE BREAT SORENESS SO I STOPPED THE CREAM TOOK THE SALIVA TEST AND MY PROGESTORONE LEVELS WERE IN THE THOUSANDS, I ONLY TOOK ABOUT 40 TO 50 MG A DAY. I SAW A BIO IDENTICAL DOCTER WHO WANTED TO PUT ME ON 80/20 BIEST SUBLINGUAL O.5 MG DAILY AND 50 MG DAILY OF SUBLINGUAL PROGESTORONE CREAM AND 0.25 MG OF DHEA SUBLINGUAL A DAY. HE SAYS THE CREAMS GET STUCK IN THE PORES AND IT CAUSES PROBLEMS HE ALSO SAYS START ON A LOW DOSE OR ILL THROUGH ALL OF THE OTHER HORMONES OFF. I HAVENT TRIED ANYTHING YET WHAT DO YOU THINK?
Oct 02, 2013
 Confused
by: Wray

Hi Debbie Progesterone levels can rise very high, see our page on Saliva Tests. It's the ratio which is critical not the level of each hormone. We also have a page on Breast Tenderness. Please read our page on Menopause too. I go into details on each page about how much progesterone to use. I'm not in favour of oestrogen, see our page on HRT. Take care Wray

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