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Confused about blood test results

by Vera
(BC)

Hello,
I have recently had blood tests done for estradiol and progesterone on day 5 of my cycle on April 16. i am definitely in perimenopause the last few years with very irregular cycles all over the place and of different lengths. I was taking some oral progesterone plus a bit of cream but stopped it all mid March. I started the cream and oral again 3 days before this recent bloodwork, totaling over 100mg actually absorbed. I am confused as to my blood test results and am hoping someone on here can help. My estradiol is at 104 pmol/L and my progesterone at 246.1 nmol/L. Can someone give me the ratio of progesterone to estradiol that these results mean? I am confused!

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Apr 25, 2025
Confused about blood test results
by: Joy

Hi Vera

You haven't given your age, but it sounds like you are in Peri-Menopause as you have all the symptoms.

Any kind oral progesterone is not the best Delivery Method as around 96% gets destroyed by the gut and liver, meaning that you would be getting very little progesterone, although your tests reveal otherwise. Between 100-200mg per day is needed using a good organic progesterone cream, such as Natpro, which was formulated over 30 years ago and is a 3% cream. Please read the How to Use Progesterone Cream and Estrogen Dominance pages.

You seem to have a high progesterone level. The ratio should be 600:1, yours is 2,366:1. Are you sure these results are correct, and what cream are you using? Please read the Hormone Testing page. I must just add that there is nothing wrong with a high P level, many women have high levels. The main thing is, how are you feeling? This could also happen if you are using a higher percentage progesterone cream.

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