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Concerned that your progesterone comes from Soya

by L

Dear Wray,

I suddenly panicked when I read your last email, as I hadn't actually realized that your progesterone came from Soya, as one of my big problems is Hypothyroidism and I know that soya supressess the thyroid which is exactly what I don't want, and also is the soya that you use organic, otherwise it will all be Genetically modified. I don't know whether I should stop using this immediately as I have had some severe fatigue and other issues since using it. Would really appreciate a reply. Thanks L

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Jan 14, 2012
 Concerned that your progesterone comes from Soya
by: Wray

Hi L We stopped using soy as the substrate from which the progesterone is synthesised in June 2010. It was causing too much confusion. In fact many people are confused about how progesterone is made and where from. This arises as so many web sites say made from yam, while others say made from soy. Interestingly, none of the pharmaceutical firms making progesterone injections or suppositories for use in IVF treatments, miscarriages or pre-term births, mention where the progesterone comes from. The bottom line is it doesn’t matter what plant is used for synthesising progesterone, providing it contains a plant sterol in sufficient quantities to make it economical. All plants have sterols, often called phytosterols.  Animals only have one sterol, more commonly known as a zoosterol, which we call cholesterol, and fungi only have one called ergosterol. They are an integral part of cell membranes and precursors to many things, for instance in animals to hormones.  But there are plant sterols and plant sterols. The phytosterols used for making progesterone do not have a triple bond in the A-ring. In fact they have no bond in the A-ring, unlike progesterone which has one.  So the molecule must be changed, this has to be done in a lab. For instance the conversion of stigmasterol to progesterone takes place over 11 reactions, each producing a different molecule. Until the final step produces progesterone and only progesterone, it would not be legal to call it progesterone if it was contaminated with soy or yam. The fatigue and other issues are due to Oestrogen Dominance. Initially progesterone stimulates oestrogen, but once it becomes the dominant hormone, the symptoms go. It's essential to make progesterone the dominant hormone, this can only happen if the amount is increased. Once all symptoms have gone, it can be reduced very slowly, by no more than 16mg/day. We have more info on our page How to use progesterone cream. Take care Wray

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