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Vitamin D and Visceral Fat

by Gigi
(Italy)

Hi, Wray!
What do You here think about the follower abstract???

Role of Calcitriol and Cortisol on Human
Adipocyte Proliferation and Oxidative and
Inflammatory Stress: A Microarray Study
Xiaocun Sun
a
Kristin L. Morris
b
Michael B. Zemel
a

a
University of Tennessee, Knoxville, Tenn. and
b
Mead-Johnson Nutritionals, Evansville, Ind. , USA

Abstract


Dietary calcium inhibits adiposity, and a key underlying
mechanism is suppression of calcitriol, which modulates
Ca 2+ signaling and mitochondrial uncoupling in adipocytes.
We demonstrated that calcitriol directly regulates adipocyte
11  -HSD-1 expression and cortisol production in human adipocytes in vitro and dietary calcium inhibits visceral adipose tissue 11  -HSD-1 expression in mice, indicating an interaction of calcitriol and cortisol in obesity. Consequently,
we have evaluated the gene expression profile of human
subcutaneous adipocytes treated with calcitriol and/or cortisone. Data analysis demonstrated significant calcitriol
modulation of gene expression toward inhibition of the adipocyte apoptosis (e.g., VEGF and STC-2) and promotion of
adipocyte proliferation (e.g., IGF-1 and IGF-1R). Calcitriol also
up-regulated oxidative stress and inflammatory genes such
as NOX-4 and TLR-3. The calcitriol/cortisone combination resulted in significant additional up-regulation of 11  -HSD-1
and down-regulation of adiponectin expression, while cortisone exerted little independent effect in the absence of
calcitriol. Overall, calcitriol stimulated a pattern of adipocyte
gene expression which favored adipocyte proliferation, oxidative and inflammatory stress and visceral adiposity, andthese effects were amplified in the presence of cortisone;
however, this conclusion must be tempered by the adipocyte source (subcutaneous) and requires confirmation in visceral adipocytes. Copyright © 2007 S. Karger AG, Basel

Comments for Vitamin D and Visceral Fat

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Jul 18, 2012
 Vitamin D and Visceral Fat
by: Wray

Hi Gigi It's not necessary to copy/paste some of the paper, please just give the URL. I did look up the full paper to understand more of it. There's no question alterations in calcium signalling increases the risk for obesity, diabetes, and metabolic syndrome, heart disease too. Although their research is extensive, and I don't doubt the validity of the aspect they looked at, what does surprise me is the conclusion that excess 1,25 vitamin D leads to oxidative stress, inflammation and adiposity. Other studies have found the opposite, see here, here, here, here, here, here, here, here and here. Calcium is interesting too, as an excess of that does lead to heart disease, plus depression and possibly ironically osteoporosis, see here, here, here, here and here. A lack of vitamin K leads to altered calcium signalling, leading to deposition in the arteries, calcium itself is inflammatory too if excess enters the cell. Vitamin K is one of the cofactors for vitamin D ensuring deposition of calcium in bones, and preventing it's deposition in arterial plaque, thereby reducing osteoporosis, calcification of arteries and cancer. This is an excellent article here. If they looked at vitamin K, they make no mention of it. Take care Wray

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