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Is progesterone making me depressed?

I have been on natural hormones (troche, which I keep in my mouth until it disolves) for about 5 weeks - they are bi-estrogen 2mg and progestrone 150mg twice a day. I have been experiencing nausea some days and mild depression, and anxiety which I never had before.

I also had itches on my arms - which I had a couple of years ago and it went away, now it has come back. Could these symptoms be caused by the progesterone?

Comments for Is progesterone making me depressed?

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Dec 29, 2008
 Is progesterone making me depressed?
by: Wray

It's more likely oestrogen causing the depression. When first using progesterone it activates the oestrogen receptors, so making oestrogen the dominant hormone. Plus you are taking extra oestrogen. This is also causing the nausea and anxiety.

We do have a web page which gives more info on what's happening to you, I'll give the link below:

Estrogen dominance
https://www.progesteronetherapy.com/estrogen-dominance.html

Take care Wray
Oct 01, 2012
 Symptoms of too much estrogen havn't gone away after 4 months of progesteone cream
by: Julia H

Dear Wray,

I am at my wits end. I have read your comments and articles. I have taken your free questionaire (scored 67, when over 10 was definate E-dominance) I ordered your cream and have used aprox a tube every 14 to 21 days for the last four months, and before that progesterelle in coconut oil at the same strengthe for 6 weeks prior. So about 5 1/2 months total of high supplementation. None of my symptoms have gone away, they have only gotten worse. So tired i cant move, depressed all the time, suicidal, wieght gain, cant fall asleep, cant stay asleep, brain fog, forgetfulness...just to name a few.

You said it would happen at first because of the progesterone mimicing oestrogen....but this is almost 6 months later, and it is a nightmare! what is happening????


Julia H
Oct 01, 2012
 Addition to-Symptoms of too much estrogen havn't gone away after 4 months of progesteone cream
by: Julia H

Dear Wray,

I just commented a moment ago. I need to add I have also cut out all parabens, use only natural soap and cleansers, completely avoid estrogen in my diet as much as humanly possible. Stopped coffee for my adrenals and exersize when I can. So I feel I have covered every possible base and it still ISNT WORKING!

thanks, Julia H
Oct 02, 2012
 Symptoms of too much estrogen havn't gone away after 4 months of progesteone cream
by: Wray

Julia H Please confirm you use the cream for only 7 days, i.e. days 14 to 21? As it should be used for 14 days, i.e. the last 14 days of your cycle. All women if ovulating, ovulate 12-14 days before bleeding. Do you have a 28 day cycle, in which case starting on day 14 is correct, but if it's longer or shorter than this, it's incorrect. We do have more info on our page How to use progesterone cream. Although I recommend 100-200mg/day, often much more is needed. If you are using the cream for only 7 days, it does mean you are getting about 286mg/day progesterone. This is an excellent amount, but should be continued for 14 days. When you stop using the cream during the follicular phase, do your symptoms come back? If so then I recommend applying the cream daily, through any bleeding, for about 2-3 months. This ensures oestrogen is suppressed and progesterone becomes dominant. Once stable the cycle can then be followed again. I'm delighted to hear you've cut out all parabens, and any oestrogens in your diet. This is difficult as all foods contain phytoestrogens. If interested these papers list the foods with the highest content, see here, here and here. These papers here and here, on infertility in sheep, show how a high level of phytoestrogens in food can affect the reproductive organs. Take care Wray

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