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Does progesterone affect oral gum tissue?

by Beth
(US)

Does progesterone cream therapy increase gingivitis and gum tissue deterioration? I have used progesterone cream for years and am planning to increase my dosage and usage days of progesterone as I am probably perimenopausal (44 yrs), but I am concerned about its effects on oral gum tissue. I already have inflamed, receding gums and probably moderate periodontal disease (visiting dentist soon). I have read (Cleveland Clinic) that rising progesterone levels in pregnant women often causes temporary gingivitis.

Can anyone provide any information on whether non-pregnant women who use natural progesterone cream experience increased gum irritation/disease?

Comments for Does progesterone affect oral gum tissue?

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May 06, 2021
 Does progesterone affect oral gum tissue?
by: Joy

Hi Beth

I would say that excess estrogen would be the culprit, not progesterone!

Wray replied to a similar question a few years ago. This is what she had to say ...

"I've not heard that progesterone can increase ginginvitis or tooth decay. One wonders if this is the case, why all pregnant women, including all pregnant female animals, don't have decayed teeth at the end of pregnancy! In women, progesterone rises from 5-20ng/ml produced during the luteal phase to over 400ng/ml in the third trimester. The Wiki page gives no reference to a study on this. I've looked through 8 pages of studies on Google scholar and found only one article, not a study. It made me laugh, as it said "Progesterone dilates blood vessels causing inflammation, and blocks the repair of collagen, the structural protein that supports the gums." How a dilating blood vessel can cause inflammation I don't know. Progesterone is a potent anti-inflammatory, it stimulates the Th2 cytokines".

You might like to read the following see
here.

Omega 3 fish oil seems to help gingivitis. Here is the link for that but you need to subscribe to access the info see here.

This is what is says on Omega 3 fish oil ....

"Omega 3 fish oil
Orally, fish oil is used for hyperlipidemia, hypertriglyceridemia, coronary heart disease, hypertension, stroke, bipolar disorder, depression, rheumatoid arthritis (RA), osteoporosis, psoriasis, atopic dermatitis, ulcerative colitis, Crohn's disease, Behcet's syndrome, and Raynaud's syndrome. Fish oil is also used orally for dry eye syndrome, weight loss, asthma, cancer, dysmenorrhea, lung diseases, allergic rhinitis, chronic fatigue syndrome (CFS), albuminuria associated with diabetic nephropathy, restenosis after angioplasty, glaucoma, miscarriage, pre-eclampsia, preterm labor, infant development, and intrauterine growth retardation. Fish oil is used for systemic lupus erythematosus (SLE), cystic fibrosis, Alzheimer's disease and other dementias, gingivitis, Lyme disease, renal impairment associated with cirrhosis, type 2 diabetes, and stable claudication. Fish oil is also used to treat attention deficit-hyperactivity disorder (ADHD), dyslexia, and dyspraxia. Other uses include preventing muscular soreness after exercise, preventing thrombosis after placement of a hemodialysis graft, renal impairment associated with IgA nephropathy; and high blood pressure and renal impairment associated with heart transplantation".

Hope this helps you.

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