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Why would progesterone shrink small but not large fibroids?

by Ata
(Canada)

Hello,

I am 56 year old and have a large 13 cm uterine fibroid. Reading about progesterone therapy, I would really like to try it..Many comments state though that large fibroids will not be helped and require surgery. Why would progesterone shrink small but not large fibroids? Is it hopeless to try? What dose should I start at with Bioidentical progesterone from a compounding pharmacy? Would I apply it vaginally? Thank you in advance for any guidance.

Ps. I have tried high dose Vitamin D along with other supplements recommended but the fibroid keeps growing.

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Feb 16, 2025
 Why would progesterone shrink small but not large fibroids?
by: Joy

Hi Ata

Fibroids like any other growth or tumour will respond quicker if addressed early. Progesterone can help the body absorb smaller ones but as mentioned, larger ones usually require surgery. I see no reason why you shouldn't try progesterone. You need it anyway as you are in Menopause.

Fibroids are caused by oxidative stress, you need to address your Inflammation and heal your gut. Fermented foods are most beneficial. Vitamin D3 and taurine are of paramount importance in their prevention, see here. A lack of taurine is found in endometrial cancer, cystic endometrial hyperplasia, fibromyoma (fibroids), and dysfunctional uterine bleeding see here. Please make sure that your Vitamin D3 level is optimal at all times.

If you decide to use progesterone from a compounding pharmacy, please make sure that it equates to that of Natpro Progesterone Cream which is a 3% organic cream and contains no parabens etc. Progesterone therapy is not a quick fix when it comes to fibroids, endometriosis etc.

Best of luck.
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Feb 18, 2025
 Follow up information
by: Ata

Thank you for your response. I just received my Vitamin D3 test result and my level is 229 nmol/L which in Canada is considered too high (I think this corresponds to 91.6 ng/mL). Could too high Vitamin D3 level make the fibroid grow? I am taking Mg plus Taurine, NAC, EGCG, eating low glycemic whole foods diet. I have not bled for a year, yet my ferritin is way below normal at 11 and my fibroid has grown. Progesterone is my hope, yet do you think it will help (and not make the fibroid grow bigger)? Have you heard of any ladies successfully shrinking/eliminating very large fibroids (12.7 cm)? I would like to use Natpro. What dosage should I start at and where do I apply it for best results? I understand this is a marathon with no guarantees. I am committed to doing whatever I need to. Thank you again for your suggestions.
Feb 19, 2025
 Follow up information
by: Joy

Hi Ata

Your D3 level is good. It should be between 70-100ng/mL. Mine is currently 130ng/mL, I feel at my best at that level. Please see the Vitamin D Council and references.

Most of the answers to your questions can be found on the fibroid page under References. All studies examining progesterone that demonstrated favourable outcomes utilized dosages ranging from 200mg to 500mg per day or 6ml to 12ml of Natpro Progesterone Cream daily. In some cases, dosages may reach as high as 600mg per day, depending on the severity of the condition. It’s recommended to apply the cream twice daily to maintain consistent levels. For optimal results, use the cream every day without interruptions until there is a noticeable improvement, after which you can begin to follow your menstrual cycle if you have one. If you believe you are stable enough to reduce your usage, please do so gradually. Your fibroid is large, I suggest a higher amount.

D3 is highly recommended we should all be taking it regardless of symptoms. I am pleased that you are taking magnesium, but what about the other cofactors? Namely vitamin K3, zinc and boron.

A missed period for 12 months puts you in Menopause.

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