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DIM

Can you tell me a little more about DIM? I've been reading on here where a lot of people are taking it and you recommend it but I would love to read some facts on it. When I researched it on the web all I came across was how it helped estrogen levels?? Also, I read breastfeeding moms shouldn't take it. I'm still breastfeeding my 14 month old. Is that problem?

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Jun 27, 2012
 DIM
by: Wray

Hi there Oestrogen is broken down into 2 principle metabolites, 2-hydroxyestrone (2-OHE1) and 16-alpha hydroxyestrone (16alpha-OHE1). 16alpha-OHE1 is regarded as a potent oestrogen, whereas 2-OHE1 is a weaker oestrogen. In some studies DIM (3,3'-Diindolylmethane) increased levels of 2-OHE1, by doing so it also increases the ratio of 2-OHE1:16alpha-OHE1. This increased ratio is associated with a lower risk for breast cancer in some studies, not in others. It appears to have a positive affect on pancreatic, thyroid, prostate and gastric cancers, and leukemia too. The precursor to DIM is Indole 3 Carbinol (I3C) which also has antioxidant and anti-cancer properties. These are a selection of papers here, here, here, here, here, here, here, here, here, here, here, here and here DIM is an oestrogen antagonist, so helps in all cases where oestrogen is in excess. A caution is always given for any substance, even natural, if breastfeeding or pregnant. No studies are done on humans due to ethical concerns. It's best to heed this, but if you want to take it, make a raw veggie juice drink with cabbage leaves in it, these are high in IC3 which converts to DIM in the gut. In fact one of the studies I've given you was done using cabbage juice. I would add some apple juice too, as cabbage juice is very potent! Take care Wray

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